HPLC Column, IEX WCX, 10um, 4.6mm ID x 250mm Length, 100A. Cogent Brand. 1 EA.
Additional Information:
Cogent IEX WCX is a weak cation exchange (WCX) HPLC stationary phase manufactured using high-purity silica and carboxylic acid functional groups that provide pH-dependent negative charge characteristics. This weak cation exchange mechanism offers selective retention and separation of positively charged analytes while allowing greater control of retention through mobile phase pH adjustments. The stationary phase is particularly useful for basic compounds, amines, peptides, and other cationic species and serves as an excellent alternative for USP L9 methods requiring weak cation exchange selectivity.
67091-25P is a 250 mm x 4.6 mm ID analytical column packed with 10 µm WCX particles with a 100 Å pore size. The extended 250 mm length provides increased theoretical plate counts and maximum resolving power for complex ion exchange separations, impurity profiling, purification studies, and challenging analytical applications requiring enhanced separation of closely related cationic compounds. The 10 µm particle size provides low backpressure and supports higher flow rates than smaller particle packings. Typical operating flow rates are approximately 1.0–3.0 mL/min on conventional HPLC systems.
This USP L9 column is particularly useful for the separation and purification of positively charged compounds, including basic pharmaceuticals, amines, peptides, alkaloids, and other cationic species. The weak cation exchange functionality allows chromatographers to optimize selectivity through pH control while maintaining excellent efficiency and reproducibility. This is one of the most popular Cogent ion exchange column configurations for demanding WCX separations requiring maximum chromatographic resolution.
Key Benefits
Weak cation exchange (WCX) stationary phase
Carboxylic acid functional groups
pH-dependent retention characteristics
Suitable alternative for USP L9 methods
10 µm particles for lower backpressure
Supports higher flow rates
Maximum resolving power from 250 mm column length
High-purity silica support
Typical Applications
USP L9 methods
Ion exchange chromatography
Basic compound analysis
Pharmaceutical analysis
Amine separations
Peptide analysis
Impurity profiling
Purification studies
Specifications
Product Type: HPLC Column
Stationary Phase: IEX WCX
USP Classification: L9
Chromatography Mode: Weak Cation Exchange
Functional Group: Carboxylic Acid
Functional pH Range: Approximately pH 2.5–7
Particle Size: 10 µm
Pore Size: 100 Å
Column Dimensions: 4.6 mm ID x 250 mm
Length: 250 mm
Recommended Flow Rate: 1.0–3.0 mL/min
Brand: Cogent
Important Notes
Designed for ion exchange chromatography
Retains positively charged analytes
Retention can be adjusted through mobile phase pH control
Longer column length provides maximum chromatographic resolution
Lower backpressure compared to smaller particle columns
Supports higher flow rates for routine and preparative methods
Excellent alternative for many USP L9 methods
One of the most popular Cogent WCX column configurations